Wayne Federman is noted for his numerous stand-up comedy appearances in clubs and on television, his biography of "Pistol" Pete Maravich, and his supporting comedic acting roles in The X-Files, The Larry Sanders Show, Curb Your Enthusiasm, Legally Blonde,  and 50 First Dates.

In 1987, Federman moved to Los Angeles and began working at the The Improv, IGBYs, The Laugh Factory, and the Comedy and Magic Club. He taped a series of televised stand-up performances including Evening At The Improv, George Schlatter's Comedy Club, CBS Morning Show, 2 Drink Minimum, Star Search, Good Times Cafe, The A-List, and MTV  Hour Comedy Hour.

He toured extensively, performing at over 200 colleges. He co-founded the improvisational group, "No Fat Guy," with Marc Raider, Scott LaRose, and Steve Hytner and later briefly formed a music comedy team with Jordan Brady.

Federman began booking television commercials and appeared in dozens of national spots for clients including: Eureka Vacuums, Holiday Inn, U.S. Navy, Wendy's, Taboo, Eagle Talon (w/ Greg Kinnear), McDonalds, Glad Bags, Sprite, Total Raisin Bran, Ford, U.S. Olympic Team, Suzuki Samurai, Sizzler, Del Monte, U.S. Cellular, Coors, and 7-11. He gained some prominence as the first "not exactly" guy in the long running Hertz rental car campaign.

Federman began landing small television parts on Baywatch, Amen, Dear John, A Different World, Doogie Howser, News Radio, and recurring roles on L.A. Law (3 episodes) and Living Single (3 episodes).

In 2004, he taped his own 1/2 hour stand-up special for the series, Comedy Central Presents.

In 2006, Federman landed the recurring role of "Johnson" on the short-lived CBS sitcom, Courting Alex.

Federman co-wrote and starred in Max and Josh, a short film that premiered at the 2006 Sundance Film Festival, where it won the Volkswagen Relentless Drive Award.

Federman filmed roles in the upcoming 20th Century Fox feature Unaccompanied Minors, and Universal's Knocked Up, scheduled for release in August 2007.