Rich Little was a frequent guest on variety and talk shows. He was a regular guest on Dean Martin's Celebrity Roasts in the 1970s and was also a regular on The Julie Andrews Hour in 1973. He was named Comedy Star of the Year by the American Guild of Variety Artists in 1974. He hosted The ABC Comedy Hour (also known as KopyKats) in 1972, The Rich Little Show in 1976, and The New You Asked For It in 1981. Little has also appeared in several movies and released nine albums.

He has been active in several charities including the Juvenile Diabetes Fund and the Children's Miracle Network. He has been named to Miami Children's Hospital International Pediatrics Hall of Fame and been honored by the naming of the Rich Little Special Care Nursery at Ottawa Civic Hospital.