Audiences regard his style to be unapologetically brazen and honest. His stand-up has been featured on Comedy Central Presents. He has also appeared on other Comedy Central shows, such as Tough Crowd with Colin Quinn and Shorties Watching Shorties, an animated series in which Nick voices the character "Baby Nick."

Nick DiPaolo also appeared at Comedy Central's Roast of Denis Leary where he tells a joke, "Denis Leary has made more bombs in the last 5 years than Hamas."