Mo Rocca is a regular panelist on NPR's Wait Wait...Don't Tell Me! and appeared in VH1's decade shows: I Love the 80s, I Love the 70s, I Love the 80s Strikes Back, I Love the 80s 3-D, I Love the 90s, I Love Toys, and I Love the 90s: Part Deux. The series officially stated his occupation as "media gadfly" for one of its incarnations, and noted his physical resemblance to the children's book character Waldo in another. He is the host of Things I Hate About You on Bravo. Rocca is also a regular correspondent for The Tonight Show with Jay Leno.

He was an on-the-floor correspondent for Larry King on CNN, at the 2004 Democratic National Convention, which he called an "Obamarama." Though occasionally making straight insights and political comments, Rocca's irrelevant and irreverent statements were a humorous contrast to King's more staid politician and pundit guests. Rocca characterized Teresa Heinz Kerry as the "Siren of the Serengeti," and expressed affinity with the statement by keynote speaker, Barack Obama, about the pains of growing up as a skinny boy with a funny name.