Macio began to observe and imitate people as well as his own idiosyncrasies. In his material, Macio, now, a father of three, confronts everything from raising his own children to his controversial views on religion.

His intellect has been instrumental in leading him to starring roles in the hit syndicated comedy series, the "Uptown Comedy Club" which he wrote and produced, hosting NBC's late night talk show "Later", and starring in his self-entitled television pilot, "The Macio Show", produced by Quincy Jones and David Salzman. Macio has also performed with other great comics including Chris Rock, Damon Wayans, Dave Chappelle, Wanda Sykes, and DL Hughley.

Since 1994, Macio has written and starred in award winning television ads for major corporations such as Burger King, Pepsi, Lincoln, and AT&T. He is responsible for the popular 1 800 CALL ATT ads starring DL Hughley, Marlon Wayans, and Charles Barkley.

Whatever the subject matter, Macio always delivers. His conversational style of humor has enough color and wit to take his audiences on a ride of fascinating observational intellect.