Lary Miller frequently portrays babbling yes-men, slightly odd friends, wisecracking professionals or other weird, support character roles. Miller had a standup special for for HBO in the 1980s.
 
Miller is also a regular political-humor columnist for The Weekly Standard, and is known for usually taking conservative positions on a variety of issues and is particularly known for his controversal anti-Palestinian, pro-Israeli positions.

Miller performs a regular comedy routine called "The Five Stages of Drinking". He has appeared in many movies including "Necessary Roughness," The Nutty Professor" and "10 Things I Hate About You."