Josh Blue was voted the "Last Comic Standing" on NBC's reality show Last Comic Standing during its fourth season.

Blue has cerebral palsy and many of his jokes center on living with his disability, how he deals with it and how other people view him. He coined the term "palsy punch" during his final set of the final round of the show, when he said that the palsy punch is effective in a fight because "first of all, they don't know where the punch is coming from, and second of all, neither do I." Blue is also an excellent soccer player and was part of the 2004 U.S. Paralympic team.

Blue got his start in comedy doing open-mic sets while attending The Evergreen State College. Audiences reacted enthusiastically to his self-deprecating humor, and Blue started making a name for himself on the comedy circuit. He has appeared several times on Comedy Central's Mind of Mencia.