In 2003, Kimmel made his debut on his own show on ABC. The show, titled Jimmy Kimmel Live, currently airs five nights a week.

 He performed two voice-overs for animated series as Death's dog in the Family Guy episode "Mr. Saturday Knight", and in "Xandir and Tim, Sitting in a Tree's" Drawn Together episode.

Jimmy Kimmel, is a talk-show host and comedian who began his radio career with the KZZP afternoon show. He later worked at KZOK as co-host of The Me and Him Show, at WRBQ in Tampa, and at KCMG-FM in Palm Springs.

It was in California where he took on Carson Daly as his intern. Kimmel also spent five years working for the Kevin and Bean morning show in Los Angeles as "Jimmy the Sports Guy."

Jimmy began his television career in the Comedy Central's game show Win Ben Stein's Money. He won an Emmy as the co-host of this show. Kimmel then served as the co-host and co-creator of The Man Show for four years. His success with the show allowed the creation and production of another TV show named Crank Yankers also on Comedy Central.