While his image and style differ markedly from most comics associated with the so-called alternative comedy scene, he performes alongside comics like David Cross and Patton Oswalt.

Greg Behrendt was a consultant for two 2001 episodes of the popular television show Sex and the City, and co-wrote the New York Times best sellers He's Just Not That Into You and It's Called a Breakup Because It's Broken.

He has appeared regularly on The Tonight Show and Late Night with Conan O'Brien. His stand up special, Greg Behrendt is Uncool, debuted on Comedy Central in January of 2006.

Greg premiered his own daily daytime talk show called The Greg Behrendt Show on Tuesday, September 12, 2006.