Best known for making fun of his obesity and his ability for impressions, Gabriel Iglesias' opening joke is "There are 5 kinds of fat": Big, Healthy, Husky, Fluffy (which he says he is) and "DAAAAAAAMN!"

Iglesias was a finalist during the fourth season of the reality television series, Last Comic Standing. In the July 11, 2006 episode, which featured the series' roast segment, he was chosen as the roast subject of the evening. The Producers evicted him before that episode's elimination round, after it was discovered that he had violated the terms of the contestants' contract on several occasions.

Gabriel's style of comedy is a mixture of story telling with characters and sound effects that bring his personal issues to life. Having the ability to crossover with his clean animated style of comedy has made him a huge demand throughout the stand-up comedy circuit.