Diane Nichols was born and raised in San Francisco in a semi-show business family. She moved to Hollywood to start a comedian career. She displayed her talents during open-mike nights and comedy clubs.

She became a regular on stage and her career moved along quickly. Diane's traveled to  comedy clubs in Denmark and Sweden as well as aboard the Princess Lines cruise ships. She has performed for a wide array of corporate audiences ranging from automobile dealerships to health care providers.

She appeared on shows like Late Night With David Letterman, and on The Tonight Show With Johnny Carson. More recently, Diane emceed the Tribute to Lucille Ball at the Academy of Motion Picture Arts & Sciences.