Bob Odenkirk is best known as David Cross's unrepentant partner on HBO's cult hit Mr. Show (and its feature film spin-off Run Ronnie Run!).

The few who don't know Bob from Mr. Show might recognize him as Garry Shandling's agent Stevie Grant from The Larry Sanders Show or as a cast member from the short-lived Ben Stiller Show.

Odenkirk worked for Saturday Night Live for a while and wrote such memorable characters as Matt Foley, Motivational Speaker, for Chris Farley. Odenkirk's other work includes writing for the TV show Get a Life, The Dennis Miller Show, and The Ben Stiller Show. Odenkirk has also made appearances on Seinfeld, Space Ghost Coast to Coast, Arrested Development, and Curb Your Enthusiasm.

Odenkirk was also the spokesperson for Miller beer in their electoral-themed commercial campaign to become "The President of Beers" during the 2004 Elections. Odenkirk has also directed the film Melvin Goes to Dinner in 2003, and Let's Go to Prison for release in November 2006.