His material usually covers the comedy industry itself, criticizing other comedians for being too predictable.

Andy Kindler played the character "Andy" a fellow sportswriter and friend of Raymond on the TV show "Everybody Loves Raymond", he is a regular guest on The Late Show with David Letterman, and a contributor to The Daily Show.

He has performed on HBO and made numerous appearances on Dr. Katz and Home Movies. He is also known for his annual "State of the Industry" address at the "Just for Laughs Comedy Festival" in Montreal. Kindler is often wrongly credited as having worked for the World Wrestling Federation as Jamison, a stereotypical nerd who was at one time the manager of the WWF tag team The Bushwhackers.