She has headlined at every major comedy club in the United States, as well as casinos in Las Vegas and Atlantic City. Adrianne has performed as far away as London, England, Melbourne, Australia and Hobart, Tasmania. She has been the opening act for Jay Leno, The Pointer Sisters, Bobby Vinton, Pat Cooper, and Billy Crystal.

Adrianne Tolsch garnered rave reviews for her performance on Broadway in 3 From Brooklyn at the Helen Hayes Theatre and co-hosted the syndicated radio show The Better Sex.

She has received two Bistro Awards and three Manhattan Association of Cabaret Awards for Outstanding Comedy Performance. Most recently she was honored with the 2004 Cabaret Hotline Award for her first one-woman show Trucks, Guns and Mayonnaise, and again in 2006 for her current show, None of Your Damn Business.